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Pulmonary Cell NewsThe authors identified elevated 15-PGDH, the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling was a major contributor to muscle atrophy in aged mice and resulted from 15-PGDH-expressing myofibers and interstitial cells within muscle.
[Science]
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Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2020). Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength. Science. https://doi.org/10.1126/science.abc8059 Cite
