Brain Ethanol Metabolism by Astrocytic ALDH2 Drives the Behavioral Effects of Ethanol Intoxication

By
Justin.choi
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The authors showed that aldehyde dehydrogenase 2 (ALDH2) was expressed in astrocytes in the mouse cerebellum and that ethanol metabolism by astrocytic ALDH2 mediated behavioral effects associated with ethanol intoxication.
[Nature Metabolism]
Jin, S., Cao, Q., Yang, F., Zhu, H., Xu, S., Chen, Q., Wang, Z., Lin, Y., Cinar, R., Pawlosky, R. J., Zhang, Y., Xiong, W., Gao, B., Koob, G. F., Lovinger, D. M., & Zhang, L. (2021). Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication. Nature Metabolism, 3(3), 337–351. https://doi.org/10.1038/s42255-021-00357-z Cite
Abstract