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Pulmonary Cell NewsThe authors report the implementation of CRISPR/Cas-9 genetic screening to identify susceptibilities of multiple A3A-expressing lung adenocarcinoma cell lines.
[PLoS Biology]
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Biayna, J., Garcia-Cao, I., Álvarez, M. M., Salvadores, M., Espinosa-Carrasco, J., McCullough, M., Supek, F., & Stracker, T. H. (2021). Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells. PLOS Biology, 19(3), e3001176. https://doi.org/10.1371/journal.pbio.3001176 Cite
