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Pulmonary Cell NewsScientists used a protein conjugation system to produce a bispecific immune engager, V-aCD3, based on recombinant VAR2CSA as the cancer targeting moiety and an anti-CD3 single-chain variable fragment linked to a single-chain Fc as the immune engager.
[Cell Death & Disease]
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Nordmaj, M. A., Roberts, M. E., Sachse, E. S., Dagil, R., Andersen, A. P., Skeltved, N., Grunddal, K. V., Erdoğan, S. M., Choudhary, S., Gustsavsson, T., Ørum-Madsen, M. S., Moskalev, I., Tian, W., Yang, Z., Clausen, T. M., Theander, T. G., Daugaard, M., Nielsen, M. A., & Salanti, A. (2021). Development of a bispecific immune engager using a recombinant malaria protein. Cell Death & Disease, 12(4), 1–11. https://doi.org/10.1038/s41419-021-03611-0 Cite
