Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function, and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.
[Molecular Psychiatry]
6807162 8N46KUHE items 1 apa 0 default asc 1 161045 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-2b9a6c55a85bd822b2dc5e46ed6f8708%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228N46KUHE%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wang%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EWang%2C%20J.%2C%20Holt%2C%20L.%20M.%2C%20Huang%2C%20H.%20H.%2C%20Sesack%2C%20S.%20R.%2C%20Nestler%2C%20E.%20J.%2C%20%26amp%3B%20Dong%2C%20Y.%20%282021%29.%20Astrocytes%20in%20cocaine%20addiction%20and%20beyond.%20%3Ci%3EMolecular%20Psychiatry%3C%5C%2Fi%3E%2C%201%26%23x2013%3B17.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01080-7%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41380-021-01080-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D8N46KUHE%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Astrocytes%20in%20cocaine%20addiction%20and%20beyond%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Junshi%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leanne%20M.%22%2C%22lastName%22%3A%22Holt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hugh%20H.%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susan%20R.%22%2C%22lastName%22%3A%22Sesack%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eric%20J.%22%2C%22lastName%22%3A%22Nestler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yan%22%2C%22lastName%22%3A%22Dong%22%7D%5D%2C%22abstractNote%22%3A%22Drug%20addiction%20remains%20a%20key%20biomedical%20challenge%20facing%20current%20neuroscience%20research.%20In%20addition%20to%20neural%20mechanisms%2C%20the%20focus%20of%20the%20vast%20majority%20of%20studies%20to%20date%2C%20astrocytes%20have%20been%20increasingly%20recognized%20as%20an%20%5Cu201caccomplice.%5Cu201d%20According%20to%20the%20tripartite%20synapse%20model%2C%20astrocytes%20critically%20regulate%20nearby%20pre-%20and%20postsynaptic%20neuronal%20substrates%20to%20craft%20experience-dependent%20synaptic%20plasticity%2C%20including%20synapse%20formation%20and%20elimination.%20Astrocytes%20within%20brain%20regions%20that%20are%20implicated%20in%20drug%20addiction%20exhibit%20dynamic%20changes%20in%20activity%20upon%20exposure%20to%20cocaine%20and%20subsequently%20undergo%20adaptive%20changes%20themselves%20during%20chronic%20drug%20exposure.%20Recent%20results%20have%20identified%20several%20key%20astrocytic%20signaling%20pathways%20that%20are%20involved%20in%20cocaine-induced%20synaptic%20and%20circuit%20adaptations.%20In%20this%20review%2C%20we%20provide%20a%20brief%20overview%20of%20the%20role%20of%20astrocytes%20in%20regulating%20synaptic%20transmission%20and%20neuronal%20function%2C%20and%20discuss%20how%20cocaine%20influences%20these%20astrocyte-mediated%20mechanisms%20to%20induce%20persistent%20synaptic%20and%20circuit%20alterations%20that%20promote%20cocaine%20seeking%20and%20relapse.%20We%20also%20consider%20the%20therapeutic%20potential%20of%20targeting%20astrocytic%20substrates%20to%20ameliorate%20drug-induced%20neuroplasticity%20for%20behavioral%20benefits.%20While%20primarily%20focusing%20on%20cocaine-induced%20astrocytic%20responses%2C%20we%20also%20include%20brief%20discussion%20of%20other%20drugs%20of%20abuse%20where%20data%20are%20available.%22%2C%22date%22%3A%222021-04-09%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41380-021-01080-7%22%2C%22ISSN%22%3A%221476-5578%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41380-021-01080-7%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-09T23%3A56%3A45Z%22%7D%7D%5D%7D
Wang, J., Holt, L. M., Huang, H. H., Sesack, S. R., Nestler, E. J., & Dong, Y. (2021). Astrocytes in cocaine addiction and beyond. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-021-01080-7 Cite
