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Pulmonary Cell NewsThe authors generated intestinal goblet cells from human epidermal stem cells with two small molecular inhibitors Repsox and CHIR99021 in the presence of basic fibroblast growth factor and bone morphogenetic protein 4 at high efficiency of conversion for a short time.
[Science Advances]
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Zhao, A., Qin, H., Sun, M., Tang, M., Mei, J., Ma, K., & Fu, X. (2021). Chemical conversion of human epidermal stem cells into intestinal goblet cells for modeling mucus-microbe interaction and therapy. Science Advances, 7(16), eabb2213. https://doi.org/10.1126/sciadv.abb2213 Cite
