Researchers report cryo-electron microscopy structures of the pore and the prepore of gasdermin D.
[Nature]
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Xia, S., Zhang, Z., Magupalli, V. G., Pablo, J. L., Dong, Y., Vora, S. M., Wang, L., Fu, T.-M., Jacobson, M. P., Greka, A., Lieberman, J., Ruan, J., & Wu, H. (2021). Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature, 1–5. https://doi.org/10.1038/s41586-021-03478-3 Cite