The authors provide insights into the mode of action of HMA, mechanisms of resistance to this treatment, and strategies to overcome HMA resistance including next-generation HMA and HMA-based combination therapies.
[Leukemia]
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Stomper, J., Rotondo, J. C., Greve, G., & Lübbert, M. (2021). Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies. Leukemia, 1–17. https://doi.org/10.1038/s41375-021-01218-0 Cite