Hyperbaric Oxygen Promotes Not Only Glioblastoma Proliferation but Also Chemosensitization by Inhibiting HIF1α/HIF2α-Sox2

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Justin.choi
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Scientists performed a series of studies and determined that the expression of HIF1α, HIF2α and Sox2 was decreased after hyperbaric oxygen (HBO) and that HBO promoted glioblastoma cell proliferation through cell cycle progression, albeit with a decrease in stemness, thus contributing to chemosensitization via the inhibition of HIF1α/HIF2α-Sox2.
[Cell Death Discovery]
Wang, P., Gong, S., Pan, J., Wang, J., Zou, D., Xiong, S., Zhao, L., Yan, Q., Deng, Y., Wu, N., & Liao, B. (2021). Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2. Cell Death Discovery, 7(1), 1–14. https://doi.org/10.1038/s41420-021-00486-0 Cite
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