A KDM4A-PAF1-Mediated Epigenomic Network Is Essential for Acute Myeloid Leukemia Cell Self-Renewal and Survival

Researchers delineated and functionally validated the epigenomic network regulated by KDM4A, and showed that selective loss of KDM4A was sufficient to induce apoptosis in a broad spectrum of human acute myeloid leukemia cells.