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Pulmonary Cell NewsScientists developed a trimeric form of the receptor binding domain and showed that it induces a potent neutralizing antibody response against live virus with diverse effector functions and provided protection against SARS-CoV-2 challenge in mice and rhesus macaques.
[Nature Communications]
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Routhu, N. K., Cheedarla, N., Bollimpelli, V. S., Gangadhara, S., Edara, V. V., Lai, L., Sahoo, A., Shiferaw, A., Styles, T. M., Floyd, K., Fischinger, S., Atyeo, C., Shin, S. A., Gumber, S., Kirejczyk, S., Dinnon, K. H., Shi, P.-Y., Menachery, V. D., Tomai, M., … Amara, R. R. (2021). SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung. Nature Communications, 12(1), 3587. https://doi.org/10.1038/s41467-021-23942-y Cite
