INO80 Promotes H2A.Z Occupancy to Regulate Cell Fate Transition in Pluripotent Stem Cells

Scientists examined the impact of Ino80 deletion in naïve and primed PSCs. They found that Ino80 deletion had minimal effect on self-renewal and gene expression in the naïve state, but led to cellular differentiation and de-repression of developmental genes in the transition toward and maintenance of the primed state.