Localized Chondro-Ossification Underlies Joint Dysfunction and Motor Deficits in the Fkbp10 Mouse Model of Osteogenesis Imperfecta

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The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. The authors generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract