Targeting Highly Pathogenic Coronavirus-Induced Apoptosis Reduces Viral Pathogenesis and Disease Severity

By
Justin.choi
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Investigators demonstrated that protein kinase R–like endoplasmic reticulum kinase (PERK) signaling mediated the proapoptotic signals in Middle East respiratory syndrome coronavirus (MERS-CoV) infection, which converged in the intrinsic apoptosis pathway.
[Science Advances]
Chu, H., Shuai, H., Hou, Y., Zhang, X., Wen, L., Huang, X., Hu, B., Yang, D., Wang, Y., Yoon, C., Wong, B. H.-Y., Li, C., Zhao, X., Poon, V. K.-M., Cai, J.-P., Wong, K. K.-Y., Yeung, M.-L., Zhou, J., Au-Yeung, R. K.-H., … Yuen, K.-Y. (2021). Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Science Advances, 7(25), eabf8577. https://doi.org/10.1126/sciadv.abf8577 Cite
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