Selenium Nanoparticles with Various Morphology for Antiangiogenesis through bFGF-Mediated P13K/AKT Signaling Pathways

Selenium nanoparticles could competitively inhibit the binding of bFGF to fibroblast growth factor receptor through direct binding to bFGF, down-regulate the expression of bFGF in HUVEC cells, and significantly reduce the MAPK/Erk and P13K/AKT pathways activation of signaling molecules to regulate HUVEC cell migration and angiogenesis.