Canagliflozin Protects against Sepsis Capillary Leak Syndrome by Activating Endothelial α1AMPK

Scientists report that canagliflozin, used at clinically relevant concentrations, counteracts lipopolysaccharide-induced vascular hyperpermeability and albumin leakage in wild-type, but not in endothelial-specific α1AMPK-knockout mice.