Lysine Acetylation Restricts Mutant IDH2 Activity to Optimize Transformation in AML Cells

Mutant IDH2 (mIDH2) R140Q commonly had K413 acetylation, which negatively regulated mIDH2 activity in human acute myeloid leukemia (AML) cells by attenuating dimerization and blocking binding of substrate (α-ketoglutarate) and cofactor (NADPH).