Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of GQ-Signaling

Activity of diacylglycerol kinase (DGK) isoforms was inhibited in human airway smooth muscle cells by siRNA-mediated knockdown of DGKα and ζ, while pharmacological inhibition was achieved by pan DGK inhibitor I.