Interactions among Diameter, Myelination, and the Na/K Pump Affect Axonal Resilience to High-Frequency Spiking

Researchers found that slowing the activation of K⁺ current can increase the Na+ influx rate, and the effect of minimizing the overlapped between Na⁺ and K⁺ currents on spike propagation resilience depended on complex interactions among diameter, myelination, and the Na/K pump density.