Induced Phase Separation of Mutant NF2 Imprisons the cGAS-STING Machinery to Abrogate Antitumor Immunity

Researchers found that Neurofibromin 2 (NF2) facilitated innate immunity by regulating YAP/TAZ-mediated TBK1 inhibition. Patient-derived individual mutations in the FERM domain of NF2 converted NF2 into a potent suppressor of cGAS-STING signaling.