ALS-Related FUS Mutations Alter Axon Growth in Motoneurons and Affect HUD/ELAVL4 and FMRP Activity

Using both human induced pluripotent stem cells and mouse models, researchers found that FUS-ALS causative mutations affect the activity of two relevant RNA-binding protein with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP.