Autophagy Is Required during High MUC2 Mucin Biosynthesis in Colonic Goblet Cells to Contend Metabolic Stress

Investigators analyzed the autophagy process in high MUC2-producing human HT29-H and a clone HT29-L silenced for MUC2 expression by lentivirus-mediated shRNA, and wild-type and CRISPR/Cas9 MUC2 KO LS174T cells.