Multipotent Progenitors and Hematopoietic Stem Cells Arise Independently from Hemogenic Endothelium in the Mouse Embryo

Researchers demonstrated by clonal assays and single-cell transcriptomics that rare hemogenic endothelium (HE) with functional HSC potential in the early murine embryo were distinct from more abundant HE with multilineage hematopoietic potential that failed to generate HSCs.