CRISPR/Cas9 Small Promoter Deletion in H19 lncRNA Is Associated with Altered Cell Morphology and Proliferation

Scientists developed a non-cancer lineage with CRISPR-Cas9-mediated H19 knockdown and observe the changes in a cellular context. To edit the promoter region of H19, two RNA guides were designed, and the murine C2C12 myoblast cells were transfected.