Reduced B7-H3 Expression by PAX3-FOXO1 Knockdown Inhibits Cellular Motility and Promotes Myogenic Differentiation in Alveolar Rhabdomyosarcoma

Researchers explored the relationship between PAX3-FOXO1 and B7-H3 and the biological roles of B7-H3 in alveolar rhabdomyosarcoma. Quantitative real time PCR and flow cytometry revealed that PAX3-FOXO1 knockdown downregulated B7-H3 expression in all the selected cell lines, suggesting that PAX3-FOXO1 positively regulates B7-H3 expression.