Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling

The authors reported an adverse effect of NEAT1, showing that the short isoform, NEAT1_1 suppressed acute myeloid leukemia (AML) development. NEAT1_1 was downregulated in leukemia stem cells and its decreased expression correlated with recurrence in AML patients.