Joint Single-Cell Multiomic Analysis in Wnt3a Induced Asymmetric Stem Cell Division

Investigators developed an approach to jointly profile the epigenome and transcriptome in the same single cell. Utilizing this method, they profiled H3K27me3 and H3K4me3 levels along with gene expression in mouse ESCs with localized Wnt3a signaling, revealing the cell type-specific maps of the epigenome and transcriptome in divided daughter cells.