TET2 Mutations Are Associated with Hypermethylation at Key Regulatory Enhancers in Normal and Malignant Hematopoiesis

Investigators reported that TET2 mutations are associated with DNA hypermethylation at enhancer sites in whole blood in clonal hematopoiesis of indeterminate potential and in both granulocytes and mononuclear cells in clonal cytopenia of undetermined significance.