Bone Marrow Derived Stromal Cells from Myelodysplastic Syndromes Are Altered but Not Clonally Mutated In Vivo

By exome sequencing of in vitro expanded mesenchymal stromal cells (MSCs) from 98 patients with myelodysplastic syndrome (MDS) and 28 healthy controls, scientists showed that these cells accumulated recurrent mutations in genes such as ZFX, RANK, and others.