The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis

Researchers analyzed MIB1 expression levels in tumor samples and performed gain- and loss-of-function studies in cell lines to investigate potential roles of MIB1 in epithelial-to-mesenchymal transition, cell migration and cell survival.