AML with Germline DDX41 Variants Is a Clinicopathologically Distinct Entity with an Indolent Clinical Course and Favorable Outcome

Investigators demonstrated that the frequent germline pathogenic DDX41 variants characterized a clinically distinct acute myeloid leukemia (AML) entity. Features characteristic of DDX41-mutated AML included male predominance, indolent course and frequent somatic DDX41 variants.