Gain-of-Function Cardiomyopathic Mutations in RBM20 Rewire Splicing Regulation and Re-Distribute Ribonucleoprotein Granules within Processing Bodies

To understand the mechanism of RBM20-associated dilated cardiomyopathy (DCM), researchers engineered isogenic iPSCs with DCM-associated missense mutations in RBM20 as well as RBM20 knockout iPSCs.