Luminescent PLGA Nanoparticles for Delivery of Darunavir to the Brain and Inhibition of Matrix Metalloproteinase-9, a Relevant Therapeutic Target of HIV-Associated Neurological Disorders

Investigators synthesized biodegradable polymeric nanoparticles loaded with darunavir and luminescent, nontoxic carbon dots, and investigated their ability to permeate through an artificial blood–brain barrier and to inhibit in vitro matrix metalloproteinase-9.