Antifibrotic Factor KLF4 Is Repressed by the miR-10/TFAP2A/TBX5 Axis in Dermal Fibroblasts: Insights from Twins Discordant for Systemic Sclerosis

The authors used global gene expression and genome-wide DNA methylation analyses of dermal fibroblasts from a unique cohort of twins discordant for systemic sclerosis to identify molecular features of this pathology.