A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

The authors presented a humanized animal model of myelofibrosis patient-derived xenografts which were robustly engrafted patient cells that recapitulated the patient’s genetic hierarchy and pathologies such as reticulin fibrosis and propagation of myeloproliferative neoplasms-initiating stem cells.