BH3-Only Proteins Puma and Beclin1 Regulate Autophagic Death in Neurons in Response to Amyloid-β

Investigators concluded that both Beclin1 and Puma played essential roles in the neuronal death caused by the induction of aberrant autophagy in Alzheimer’s disease and that targeting their interaction could be vital to understand the crosstalk of autophagy and apoptosis.