P2X7 Promotes Metastatic Spreading and Triggers Release of miRNA-Containing Exosomes and Microvesicles from Melanoma Cells

Tumor growth and metastasis are heavily affected by the P2X7 receptor and microvesicles and exosomes released into the microenvironment. Researchers showed that P2X7 was overexpressed in patients affected by metastatic malignant melanoma and its expression was closely correlated with reduced overall survival.