Endothelial Deletion of SHP2 Suppresses Tumor Angiogenesis and Promotes Vascular Normalization

SHP2 inefficiency impaired endothelial cell proliferation, migration, and tubulogenesis through downregulating the expression of proangiogenic SRY-Box transcription factor 7 (SOX7), whose re-expression restored endothelial function in SHP2-knockdown cells and tumor growth, angiogenesis, and vascular abnormalization in Shp2-deleted mice.