KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene Expression Programs

To identify key epigenetic regulators of acute myeloid leukemia (AML) cell fate, researchers performed a differentiation-focused CRISPR screen in AML cells, which identified the histone acetyltransferase KAT6A as a novel regulator of myeloid differentiation that drives critical leukemogenic gene expression programs.