Development of a Novel and Synthetic HematoMiR Technology That Broadly Modulates Quiescence of Stem Cells and Enhances HSC Expansion

Researchers showed that HematoMiRs and their combinations targeting over 50 factors involved in HSC quiescence could induce robust ex vivo murine and human HSC expansion. In particular, HematoMiR-5 treatment enhanced cell cycle through down-regulation of negative cell cycle regulators in HSCs.