A Noncanonical Hedgehog Signaling Exerts a Tumor-Promoting Effect on Pancreatic Cancer Cells via Induction of Osteopontin Expression

Researchers analyzed the correlation between Sonic Hedgehog or Gli1 and osteopontin expression in human pancreatic ductal adenocarcinoma. They also evaluated the proliferation, apoptosis, migration, and invasion of Gli1-knockdown BxPC-3 cells.