Human Gut-Microbiome-Derived Propionate Coordinates Proteasomal Degradation via HECTD2 Upregulation to Target EHMT2 in Colorectal Cancer

Researchers showed that propionate suppressed colorectal cancer growth by promoting the proteasomal degradation of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) through HECT domain E3 ubiquitin protein ligase 2 (HECTD2) upregulation.