The ERα/KDM6B Regulatory Axis Modulates Osteogenic Differentiation in Human Mesenchymal Stem Cells

Researchers found that estrogen significantly induced the expression of lysine-specific demethylase 6B (KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of dental mesenchymal stromal cells.