Targeting HIF-1α/NOTCH1 Pathway Eliminates CD44+ Cancer Stem-Like Cell Phenotypes, Malignancy, and Resistance to Therapy in Head and Neck Squamous Cell Carcinoma

Scientists compared the gene expression between CD44⁺ and CD44⁻ HNSCC cells and assessed the correlation of CD44 and hypoxia-inducible factor 1α expression with mouse features and outcomes of patients with head and neck squamous cell carcinomas.