Recapitulating Human Cardio-Pulmonary Co-development Using Simultaneous Multilineage Differentiation of Pluripotent Stem Cells

The authors reported a novel stepwise strategy for directing the simultaneous induction of both mesoderm-derived cardiac and endoderm-derived lung epithelial lineages within a single differentiation of human iPSCs via temporal specific tuning of WNT and nodal signaling in the absence of exogenous growth factors.