Eukaryotic Initiation Factor 6 Regulates Mechanical Responses in Endothelial Cells

Eukaryotic initiation factor 6 (eIF6)-depleted endothelial cells, under basal conditions, exhibit unchanged nascent protein synthesis, polysome profiles, and cytoskeleton protein expression. The authors showed that eIF6 was required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6–RACK1–ERK1/2–FAK mechanocomplex