BACE2 Variant Identified from HSCR Patient Causes AD-Like Phenotypes in hPSC-Derived Brain Organoids

Using the human pluripotent stem cell (hPSC)-derived brain organoids (BOs), investigators demonstrated that β-site APP-cleaving enzyme 2 (BACE2) was mainly expressed in the ventricular zone and cortical plate of BOs, and its expression level was gradually increased along with the BO maturation.