Tollip Interaction with STAT3: A Novel Mechanism to Regulate Human Airway Epithelial Responses to Type 2 Cytokines

Toll-interacting protein (Tollip) deficient primary human airway epithelial cells from four healthy donors were generated by the gene knockdown approach and stimulated with IL-13 to measure activation of transcription factor STAT3, and eotaxin-3, an eosinophilic chemokine.