VCAM1 Confers Innate Immune Tolerance on Haematopoietic and Leukaemic Stem Cells

Scientists showed that VCAM1 was also expressed on healthy haematopoietic stem cells and upregulated on leukaemic stem cells, where it served as a quality-control checkpoint for entry into bone marrow by providing ‘don’t-eat-me’ stamping in the context of major histocompatibility complex class-I presentation.