Maladaptive Trained Immunity and Clonal Hematopoiesis as Potential Mechanistic Links between Periodontitis and Inflammatory Comorbidities

The authors review two newly emerged concepts, trained innate immunity and clonal hematopoiesis of indeterminate potential, which together support a potential hypothesis on how periodontitis affects and is affected by comorbidities and why the susceptibility to periodontitis and comorbidities increases with aging.